BDBM50050467 1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperidin-4-ol::3-[4-(4-chlorophenyl)-4-hydroxypiperidinyl]methylindole::4-(4-Chloro-phenyl)-1-(1H-indol-3-ylmethyl)-piperidin-4-ol::CHEMBL445102::L-741626::L741,626

SMILES OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)cc1

InChI Key InChIKey=LLBLNMUONVVVPG-UHFFFAOYSA-N

Data  44 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50050467   

TargetD(3) dopamine receptor(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50050467(1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperi...)
Affinity DataKi:  49nMAssay Description:Displacement of [3H]methylspiperone from human D3 receptor expressed in HEK293 cell membrane after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50050467(1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperi...)
Affinity DataKi:  54nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50050467(1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperi...)
Affinity DataKi:  60nMAssay Description:Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50050467(1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperi...)
Affinity DataKi:  63.1nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50050467(1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperi...)
Affinity DataKi:  87nMAssay Description:Compound was measured for its ability to compete with [3H]spiperone binding to the human Dopamine receptor D3 transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50050467(1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperi...)
Affinity DataKi:  87.1nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50050467(1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperi...)
Affinity DataKi:  100nMAssay Description:Binding affinity towards cloned human Dopamine receptor D3 stably expressed in CHO cells was evaluated using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50050467(1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperi...)
Affinity DataKi:  104nMAssay Description:Displacement of [125I]ABN from human dopamine D3 receptor expressed in HEK293 cells after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50050467(1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperi...)
Affinity DataKi:  163nMAssay Description:Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50050467(1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperi...)
Affinity DataKi:  163nMAssay Description:Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50050467(1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperi...)
Affinity DataEC50:  90.4nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50050467(1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperi...)
Affinity DataIC50:  90.4nMAssay Description:Antagonist activity at dopamine D3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed